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Image Search Results
Journal: medRxiv
Article Title: Type I, II, and III interferon signatures correspond to COVID-19 disease severity
doi: 10.1101/2021.03.10.21253317
Figure Lengend Snippet: The plasma concentration of (A) IFN-α, (B) IFN-γ, and (C) IFN-λ1/3 of each disease severity (Conv: Convalescence, n= 19; Out: Outpatients, n= 23; Mild: Hospitalization under non-ICU condition, n= 23; ICU: Hospitalization in ICU, n= 23). The levels of IFN-α, IFN-γ, and IFN-λ1/3 were subdivided into within 14 days after symptom onset (DfSO) and between 15 to 26 DfSO. The detection limits are indicated by dotted lines. (D) Heatmap clustering of the plasma levels of IRF-1 related cytokines and chemokines. The value of concentration was transformed into z-score for heatmap analysis. Heatmap clustering of plasma cytokines and chemokines yielded two major clusters: IFN-γ cluster and IRF-1 cluster. z-scores of cytokines and chemokines belonging to IFN-γ cluster or IRF-1 cluster were averaged in each patient and then compared by disease severity. Significance testing among groups was performed using Kruskal-Wallis test with Dunn’s multiple comparisons test. * P<0.05, ** P<0.01, *** P<0.001, **** P<0.0001.
Article Snippet: The plasma levels of
Techniques: Concentration Assay, Transformation Assay
Journal: medRxiv
Article Title: Type I, II, and III interferon signatures correspond to COVID-19 disease severity
doi: 10.1101/2021.03.10.21253317
Figure Lengend Snippet: Normalized mRNA expression levels of antiviral genes (A) and IRF-1 related genes (B) in PBMCs were transformed into z-score and visualized in the form of heatmap. Average z-scores of antiviral genes or IRF-1 related genes were compared by disease severity. (C) Correlation between the IFN-α levels and the average z-scores of antiviral genes or IRF-1 related genes. Spearman’s rank test was used for the correlations. The regression line (solid) are shown. (D) mRNA expression levels of IFN-γ stimulated genes. Significance testing among groups was performed using Kruskal-Wallis test with Dunn’s multiple comparisons test.* P<0.05, ** P<0.01, *** P<0.001, **** P<0.0001.
Article Snippet: The plasma levels of
Techniques: Expressing, Transformation Assay